癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SPN Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant SPN.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P16150 |
| Other Accession | BC012350 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 3G8 |
| Calculated MW | 40322 Da |
| Gene ID | 6693 |
|---|---|
| Other Names | Leukosialin, Galactoglycoprotein, GALGP, Leukocyte sialoglycoprotein, Sialophorin, CD43, SPN, CD43 |
| Target/Specificity | SPN (AAH12350, 1 a.a. ~ 400 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SPN Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Sialophorin (leukosialin) is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which appears to be important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation.
REFERENCES
Binding of the Streptococcus gordonii DL1 surface protein Hsa to the host cell membrane glycoproteins CD11b, CD43, and CD50. Urano-Tashiro Y, et al. Infect Immun, 2008 Oct. PMID 18678668.The cleavage of neutrophil leukosialin (CD43) by cathepsin G releases its extracellular domain and triggers its intramembrane proteolysis by presenilin/gamma-secretase. Mambole A, et al. J Biol Chem, 2008 Aug 29. PMID 18586676.The selective expression of CD43 in adenoid cystic carcinoma. Seethala RR, et al. Appl Immunohistochem Mol Morphol, 2008 Mar. PMID 18227725.LFA-1-mediated leukocyte adhesion regulated by interaction of CD43 with LFA-1 and CD147. Khunkaewla P, et al. Mol Immunol, 2008 Mar. PMID 17996943.Site-specific morphologic differences in extranodal marginal zone B-cell lymphomas. Rawal A, et al. Arch Pathol Lab Med, 2007 Nov. PMID 17979485.
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