癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ST8SIA2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant ST8SIA2.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q92186 |
| Other Accession | NM_006011 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 6G6 |
| Calculated MW | 42430 Da |
| Gene ID | 8128 |
|---|---|
| Other Names | Alpha-2, 8-sialyltransferase 8B, 2499-, Sialyltransferase 8B, SIAT8-B, Sialyltransferase St8Sia II, ST8SiaII, Sialyltransferase X, STX, ST8SIA2, SIAT8B, STX |
| Target/Specificity | ST8SIA2 (NP_006002, 40 a.a. ~ 146 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | ST8SIA2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29.
REFERENCES
A genome-wide scan for common alleles affecting risk for autism. Anney R, et al. Hum Mol Genet, 2010 Aug 16. PMID 20663923.Identification of sequences in the polysialyltransferases ST8Sia II and ST8Sia IV that are required for the protein-specific polysialylation of the neural cell adhesion molecule, NCAM. Foley DA, et al. J Biol Chem, 2009 Jun 5. PMID 19336400.Positive association between SIAT8B and schizophrenia in the Chinese Han population. Tao R, et al. Schizophr Res, 2007 Feb. PMID 17126533.Association between polymorphisms in the promoter region of the sialyltransferase 8B (SIAT8B) gene and schizophrenia. Arai M, et al. Biol Psychiatry, 2006 Apr 1. PMID 16229822.Valproic acid modulates NCAM polysialylation and polysialyltransferase mRNA expression in human tumor cells. Beecken WD, et al. Int Immunopharmacol, 2005 Apr. PMID 15710344.
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