癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
STAM2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant STAM2.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IP, E |
|---|---|
| Primary Accession | O75886 |
| Other Accession | NM_005843 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 1A10 |
| Calculated MW | 58164 Da |
| Gene ID | 10254 |
|---|---|
| Other Names | Signal transducing adapter molecule 2, STAM-2, Hrs-binding protein, STAM2, HBP |
| Target/Specificity | STAM2 (NP_005834, 416 a.a. ~ 525 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IP~~N/A E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | STAM2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation.
REFERENCES
PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2. Stuible M, et al. J Biol Chem, 2010 Jul 30. PMID 20504764.An empirical framework for binary interactome mapping. Venkatesan K, et al. Nat Methods, 2009 Jan. PMID 19060904.STAM adaptor proteins interact with COPII complexes and function in ER-to-Golgi trafficking. Rismanchi N, et al. Traffic, 2009 Feb. PMID 19054391.E3-independent monoubiquitination of ubiquitin-binding proteins. Hoeller D, et al. Mol Cell, 2007 Jun 22. PMID 17588522.Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation. Kong C, et al. J Biol Chem, 2007 May 18. PMID 17403676.
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