癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
STAMBP Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant STAMBP.
- 产品详情
- 实验流程
- 背景知识
Application 
| IF, E |
|---|---|
| Primary Accession | O95630 |
| Other Accession | BC065574 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a kappa |
| Clone Names | 1A8 |
| Calculated MW | 48077 Da |
| Gene ID | 10617 |
|---|---|
| Other Names | STAM-binding protein, 3419-, Associated molecule with the SH3 domain of STAM, Endosome-associated ubiquitin isopeptidase, STAMBP, AMSH |
| Target/Specificity | STAMBP (AAH65574, 1 a.a. ~ 424 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | STAMBP Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
REFERENCES
AMSH interacts with ESCRT-0 to regulate the stability and trafficking of CXCR4. Sierra MI, et al. J Biol Chem, 2010 Apr 30. PMID 20159979.Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site. Wang P, et al. BMC Genomics, 2009 Nov 12. PMID 19906316.Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2. Hasdemir B, et al. J Biol Chem, 2009 Oct 9. PMID 19684015.Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.An empirical framework for binary interactome mapping. Venkatesan K, et al. Nat Methods, 2009 Jan. PMID 19060904.
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