癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SUFU Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant SUFU.
- 产品详情
- 实验流程
- 背景知识
Application 
| E |
|---|---|
| Primary Accession | Q9UMX1 |
| Other Accession | BC013291 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 1B2 |
| Calculated MW | 53947 Da |
| Gene ID | 51684 |
|---|---|
| Other Names | Suppressor of fused homolog, SUFUH, SUFU |
| Target/Specificity | SUFU (AAH13291, 181 a.a. ~ 280 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SUFU Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.
REFERENCES
Incomplete penetrance of the predisposition to medulloblastoma associated with germ-line SUFU mutations. Brugi?res L, et al. J Med Genet, 2010 Feb. PMID 19833601.Identification of a SUFU germline mutation in a family with Gorlin syndrome. Pastorino L, et al. Am J Med Genet A, 2009 Jul. PMID 19533801.Expression of sonic hedgehog signaling molecules in normal, hyperplastic and carcinomatous endometrium. Kim KH, et al. Pathol Int, 2009 May. PMID 19432668.Role and regulation of human tumor suppressor SUFU in Hedgehog signaling. Cheng SY, et al. Adv Cancer Res, 2008. PMID 19055941.MicroRNA expression changes during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal, a product of lipid peroxidation. Pizzimenti S, et al. Free Radic Biol Med, 2009 Jan 15. PMID 19022373.
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