癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SVIL Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant SVIL.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E |
|---|---|
| Primary Accession | O95425 |
| Other Accession | NM_003174 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 6E11 |
| Calculated MW | 247746 Da |
| Gene ID | 6840 |
|---|---|
| Other Names | Supervillin, Archvillin, p205/p250, SVIL |
| Target/Specificity | SVIL (NP_003165, 1679 a.a. ~ 1786 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SVIL Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Two transcript variants encoding different isoforms of supervillin have been described.
REFERENCES
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.The membrane-associated protein, supervillin, accelerates F-actin-dependent rapid integrin recycling and cell motility. Fang Z, et al. Traffic, 2010 Jun. PMID 20331534.How to arm a supervillin: designing F-actin binding activity into supervillin headpiece. Brown JW, et al. J Mol Biol, 2009 Oct 30. PMID 19683541.Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency. Crowley JL, et al. Mol Biol Cell, 2009 Feb. PMID 19109420.Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. Horikawa Y, et al. Clin Cancer Res, 2008 Dec 1. PMID 19047128.
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