癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SYNJ1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant SYNJ1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | O43426 |
| Other Accession | NM_003895 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 1A2 |
| Calculated MW | 173103 Da |
| Gene ID | 8867 |
|---|---|
| Other Names | Synaptojanin-1, Synaptic inositol 1, 5-trisphosphate 5-phosphatase 1, SYNJ1, KIAA0910 |
| Target/Specificity | SYNJ1 (NP_003886, 1474 a.a. ~ 1573 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SYNJ1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Synaptojanin 1 is a phosphoinositide phosphatase that regulates levels of membrane phosphatidylinositol-4,5-bisphosphate. As such, expression of this enzyme may affect synaptic transmission and membrane trafficking.
REFERENCES
Alternative splicing affecting the SH3A domain controls the binding properties of intersectin 1 in neurons. Tsyba L, et al. Biochem Biophys Res Commun, 2008 Aug 8. PMID 18539136.Root hair defective4 encodes a phosphatidylinositol-4-phosphate phosphatase required for proper root hair development in Arabidopsis thaliana. Thole JM, et al. Plant Cell, 2008 Feb. PMID 18281508.Two synaptojanin 1 isoforms are recruited to clathrin-coated pits at different stages. Perera RM, et al. Proc Natl Acad Sci U S A, 2006 Dec 19. PMID 17158794.Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1. Yeow-Fong L, et al. FEBS Lett, 2005 Sep 12. PMID 16137687.
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