癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
T Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant T.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | O15178 |
| Other Accession | NM_003181 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 5H8 |
| Calculated MW | 47443 Da |
| Gene ID | 6862 |
|---|---|
| Other Names | Brachyury protein, Protein T, T |
| Target/Specificity | T (NP_003172, 222 a.a. ~ 320 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | T Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells.
REFERENCES
Revisiting chordoma with brachyury, a new age marker: analysis of a validation study on 51 cases. Jambhekar NA, et al. Arch Pathol Lab Med, 2010 Aug. PMID 20670140.Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities. Docherty SJ, et al. BMC Genet, 2010 Jul 5. PMID 20602751.T (brachyury) gene duplication confers major susceptibility to familial chordoma. Yang XR, et al. Nat Genet, 2009 Nov. PMID 19801981.Brachyury, SOX-9, and podoplanin, new markers in the skull base chordoma vs chondrosarcoma differential: a tissue microarray-based comparative analysis. Oakley GJ, et al. Mod Pathol, 2008 Dec. PMID 18820665.Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification. Bondue A, et al. Cell Stem Cell, 2008 Jul 3. PMID 18593560.
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