癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TAC3 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant TAC3.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UHF0 |
| Other Accession | BC032145 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 2D7 |
| Calculated MW | 13438 Da |
| Gene ID | 6866 |
|---|---|
| Other Names | Tachykinin-3, ZNEUROK1, Neurokinin-B, NKB, Neuromedin-K, TAC3, NKNB |
| Target/Specificity | TAC3 (AAH32145, 17 a.a. ~ 121 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | TAC3 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded protein is primarily expressed in the central and peripheral nervous system and functions as a neurotransmitter. This protein is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternate splicing results in multiple transcript variants.
REFERENCES
Common variants of the neuropeptide expressing tachykinin genes and susceptibility to asthma: a case-control study. Klassert TE, et al. J Neuroimmunol, 2010 Oct 8. PMID 20580442.Neurokinin B and its receptor in hypogonadotropic hypogonadism. Semple RK, et al. Front Horm Res, 2010. PMID 20389091.TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthood. Gianetti E, et al. J Clin Endocrinol Metab, 2010 Jun. PMID 20332248.TAC3 and TACR3 defects cause hypothalamic congenital hypogonadotropic hypogonadism in humans. Young J, et al. J Clin Endocrinol Metab, 2010 May. PMID 20194706.Neurokinin B signaling in puberty: human and animal studies. Topaloglu AK. Mol Cell Endocrinol, 2010 Aug 5. PMID 20176081.
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