癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TAX1BP1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant TAX1BP1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q86VP1 |
| Other Accession | NM_006024 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 2C3 |
| Calculated MW | 90877 Da |
| Gene ID | 8887 |
|---|---|
| Other Names | Tax1-binding protein 1, TRAF6-binding protein, TAX1BP1, T6BP |
| Target/Specificity | TAX1BP1 (NP_006015, 690 a.a. ~ 789 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | TAX1BP1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The HTLV-1 Tax protein transcriptionally activates the HTLV-1 promoter. Tax also binds to and stimulates the expression of cellular genes, including transcription factors and other proteins (Gachon et al., 1998 [PubMed 9733879]).
REFERENCES
Analysis of the TAX1BP1 gene in head and neck cancer patients. Ruiz MT, et al. Braz J Otorhinolaryngol, 2010 Apr. PMID 20549079.TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinases. Parvatiyar K, et al. J Biol Chem, 2010 May 14. PMID 20304918.Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes. Shembade N, et al. Science, 2010 Feb 26. PMID 20185725.The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling. Shembade N, et al. EMBO J, 2009 Mar 4. PMID 19131965.Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. Dieguez-Gonzalez R, et al. Ann Rheum Dis, 2009 Apr. PMID 18434448.
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