癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TAZ Antibody (monoclonal) (M19)
Mouse monoclonal antibody raised against a full length recombinant TAZ.
- 产品详情
- 实验流程
- 背景知识
Application 
| IF, E |
|---|---|
| Primary Accession | Q16635 |
| Other Accession | BC011515 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 3C10 |
| Calculated MW | 30203 Da |
| Gene ID | 6901 |
|---|---|
| Other Names | Tafazzin, Protein G45, TAZ, EFE2, G45 |
| Target/Specificity | TAZ (AAH11515, 1 a.a. ~ 262 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | TAZ Antibody (monoclonal) (M19) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a protein that is expressed at high levels in cardiac and skeletal muscle. Mutations in this gene have been associated with a number of clinical disorders including Barth syndrome, dilated cardiomyopathy (DCM), hypertrophic DCM, endocardial fibroelastosis, and left ventricular noncompaction (LVNC). Multiple transcript variants encoding different isoforms have been described. A long form and a short form of each of these isoforms is produced; the short form lacks a hydrophobic leader sequence and may exist as a cytoplasmic protein rather than being membrane-bound. Other alternatively spliced transcripts have been described but the full-length nature of all these transcripts is not known.
REFERENCES
A novel custom resequencing array for dilated cardiomyopathy. Zimmerman RS, et al. Genet Med, 2010 May. PMID 20474083.Human transcriptional coactivator with PDZ-binding motif (TAZ) is downregulated during decidualization. Strakova Z, et al. Biol Reprod, 2010 Jun. PMID 20164440.Characterization of tafazzin splice variants from humans and fruit flies. Xu Y, et al. J Biol Chem, 2009 Oct 16. PMID 19700766.Mutations in TAZ/WWTR1, a co-activator of NKX2.1 and PAX8 are not a frequent cause of thyroid dysgenesis. Ferrara AM, et al. J Endocrinol Invest, 2009 Mar. PMID 19542741.TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. Zhang H, et al. J Biol Chem, 2009 May 15. PMID 19324877.
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