癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TDO2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant TDO2.
- 产品详情
- 实验流程
- 背景知识
Application 
| E |
|---|---|
| Primary Accession | P48775 |
| Other Accession | NM_005651 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 1C8 |
| Calculated MW | 47872 Da |
| Gene ID | 6999 |
|---|---|
| Other Names | Tryptophan 2, 3-dioxygenase {ECO:0000255|HAMAP-Rule:MF_03020}, TDO {ECO:0000255|HAMAP-Rule:MF_03020}, 1131111 {ECO:0000255|HAMAP-Rule:MF_03020}, Tryptamin 2, 3-dioxygenase {ECO:0000255|HAMAP-Rule:MF_03020}, Tryptophan oxygenase {ECO:0000255|HAMAP-Rule:MF_03020}, TO {ECO:0000255|HAMAP-Rule:MF_03020}, TRPO {ECO:0000255|HAMAP-Rule:MF_03020}, Tryptophan pyrrolase {ECO:0000255|HAMAP-Rule:MF_03020}, Tryptophanase {ECO:0000255|HAMAP-Rule:MF_03020}, TDO2 {ECO:0000255|HAMAP-Rule:MF_03020}, TDO |
| Target/Specificity | TDO2 (NP_005642, 307 a.a. ~ 405 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | TDO2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Tryptophan 2,3-dioxygenase (EC 1.13.11.11) plays a role in catalyzing the first and rat-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism.
REFERENCES
First genome-wide association scan on neurophysiological endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic children. Roeske D, et al. Mol Psychiatry, 2009 Sep 29. PMID 19786962.Antimicrobial and immunoregulatory properties of human tryptophan 2,3-dioxygenase. Schmidt SK, et al. Eur J Immunol, 2009 Oct. PMID 19637229.Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder. Miller CL, et al. Schizophr Res, 2009 Sep. PMID 19502010.Cooperative binding of L-trp to human tryptophan 2,3-dioxygenase: resonance Raman spectroscopic analysis. Fukumura E, et al. J Biochem, 2009 Apr. PMID 19218188.A kinetic, spectroscopic, and redox study of human tryptophan 2,3-dioxygenase. Basran J, et al. Biochemistry, 2008 Apr 22. PMID 18370401.
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