癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TEAD4 Antibody (monoclonal) (M12)
Mouse monoclonal antibody raised against a full length recombinant TEAD4.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q15561 |
| Other Accession | BC015497 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 1D10 |
| Calculated MW | 48329 Da |
| Gene ID | 7004 |
|---|---|
| Other Names | Transcriptional enhancer factor TEF-3, TEA domain family member 4, TEAD-4, Transcription factor 13-like 1, Transcription factor RTEF-1, TEAD4, RTEF1, TCF13L1, TEF3 |
| Target/Specificity | TEAD4 (AAH15497, 1 a.a. ~ 361 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | TEAD4 Antibody (monoclonal) (M12) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene.
REFERENCES
TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. Zhang H, et al. J Biol Chem, 2009 May 15. PMID 19324877.Transcription enhancer factor 3 (TEF3) mediates the expression of Down syndrome candidate region 1 isoform 1 (DSCR1-1L) in endothelial cells. Liu X, et al. J Biol Chem, 2008 Dec 5. PMID 18840614.TEAD mediates YAP-dependent gene induction and growth control. Zhao B, et al. Genes Dev, 2008 Jul 15. PMID 18579750.Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies. Sakai N, et al. J Endocrinol, 2008 Sep. PMID 18579725.Identification of novel alternatively spliced isoforms of RTEF-1 within human ocular vascular endothelial cells and murine retina. Appukuttan B, et al. Invest Ophthalmol Vis Sci, 2007 Aug. PMID 17652751.
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