癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TFCP2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant TFCP2.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q12800 |
| Other Accession | BC003634 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG2a lambda |
| Clone Names | 3H6 |
| Calculated MW | 57256 Da |
| Gene ID | 7024 |
|---|---|
| Other Names | Alpha-globin transcription factor CP2, SAA3 enhancer factor, Transcription factor LSF, TFCP2, LSF, SEF |
| Target/Specificity | TFCP2 (AAH03634, 414 a.a. ~ 502 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | TFCP2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease.
REFERENCES
Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma. Yoo BK, et al. Proc Natl Acad Sci U S A, 2010 May 4. PMID 20404171.The male-determining gene SRY is a hybrid of DGCR8 and SOX3, and is regulated by the transcription factor CP2. Sato Y, et al. Mol Cell Biochem, 2010 Apr. PMID 19902333.No replication of genetic association between candidate polymorphisms and Alzheimer's disease. Cousin E, et al. Neurobiol Aging, 2009 Nov 2. PMID 19889475.The fold recognition of CP2 transcription factors gives new insights into the function and evolution of tumor suppressor protein p53. Kokoszynska K, et al. Cell Cycle, 2008 Sep 15. PMID 18787404.PHB2 interacts with RNF2 and represses CP2c-stimulated transcription. Lee SJ, et al. Mol Cell Biochem, 2008 Dec. PMID 18629613.
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