TFF3 Antibody (monoclonal) (M01)

Provided below are standard protocols that you may find useful for product applications.

BACKGROUND

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.

REFERENCES

1.Circulating Serum Trefoil Factor 3 (TFF3) Is Dramatically Increased in Chronic Kidney Disease.Du TY, Luo HM, Qin HC, Wang F, Wang Q, Xiang Y, Zhang YPLoS One. 2013 Nov 25;8(11):e80271. doi: 10.1371/journal.pone.0080271.2.Reproducibility of histological cell type in high-grade endometrial carcinoma.Han G, Sidhu D, Duggan MA, Arseneau J, Cesari M, Clement PB, Ewanowich CA, Kalloger SE, Kobel MMod Pathol. 2013 Jun 28. doi: 10.1038/modpathol.2013.102.3.Fresh and cryopreserved amniotic membrane secrete the trefoil factor family peptide 3 that is well known to promote wound healing.Schulze U, Hampel U, Sel S, Goecke TW, Thale V, Garreis F, Paulsen F.Histochem Cell Biol. 2012 Apr 3. [Epub ahead of print]4.Profiling of differentially expressed proteins in stage IV Colorectal cancers with good and poor outcomes.Kim HJ, Kang UB, Lee H, Jung JH, Lee ST, Yu MH, Kim H, Lee C.J Proteomics. 2011 Dec 10.5.Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate.Proia TA, Keller PJ, Gupta PB, Klebba I, Jones AD, Sedic M, Gilmore H, Tung N, Naber SP, Schnitt S, Lander ES, Kuperwasser C.Cell Stem Cell. 2011 Feb 4;8(2):149-63.6.Identification of serum biomarkers for colorectal cancer metastasis using a differential secretome approach.Xue H, Lu B, Zhang J, Wu M, Huang Q, Wu Q, Sheng H, Wu D, Hu J, Lai M.J Proteome Res. 2010 Jan;9(1):545-55.7.Trefoil factor 3: a novel serum marker identified by gene expression profiling in high-grade endometrial carcinomas.Bignotti E, Ravaggi A, Tassi RA, Calza S, Rossi E, Falchetti M, Romani C, Bandiera E, Odicino FE, Pecorelli S, Santin AD.Br J Cancer. 2008 Sep 2;99(5):768-73.