癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TGFB1I1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant TGFB1I1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | O43294 |
| Other Accession | BC032545 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 4B2-D8 |
| Calculated MW | 49814 Da |
| Gene ID | 7041 |
|---|---|
| Other Names | Transforming growth factor beta-1-induced transcript 1 protein, Androgen receptor coactivator 55 kDa protein, Androgen receptor-associated protein of 55 kDa, Hydrogen peroxide-inducible clone 5 protein, Hic-5, TGFB1I1, ARA55 |
| Target/Specificity | TGFB1I1 (AAH32545, 1 a.a. ~ 444 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | TGFB1I1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Paxillin and hydrogen peroxide-inducible clone 5 expression and distribution in control and Alzheimer disease hippocampi. Caltagarone J, et al. J Neuropathol Exp Neurol, 2010 Apr. PMID 20448481.In vitro and in vivo evidence of pathogenic roles of Hic-5/ARA55 in keloids through Smad pathway and profibrotic transcription. Inui S, et al. J Dermatol Sci, 2010 May. PMID 20395114.Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity. Jones CA, et al. Nat Cell Biol, 2009 Nov. PMID 19855388.The progesterone receptor coactivator Hic-5 is involved in the pathophysiology of endometriosis. Aghajanova L, et al. Endocrinology, 2009 Aug. PMID 19389829.Smad7 is inactivated through a direct physical interaction with the LIM protein Hic-5/ARA55. Wang H, et al. Oncogene, 2008 Nov 20. PMID 18762808.
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