癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TKTL1 Antibody (monoclonal) (M01)
Purified Mouse Monoclonal Antibody (Mab)
- 产品详情
- 实验流程
| Primary Accession | P51854 |
|---|---|
| Reactivity | Human |
| Host | mouse |
| Isotype | IgG1 Kappa |
| Clone Names | 1C10 |
| Calculated MW | 65333 Da |
| Gene ID | 8277 |
|---|---|
| Other Names | Transketolase-like protein 1, Transketolase 2, TK 2, Transketolase-related protein, TKTL1, TKR, TKT2 |
| Target/Specificity | TKTL1 (AAH25382, 1 a.a. ~ 597 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | TKTL1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Expression of transketolase-like 1 protein (TKTL1) in human endometrial cancer. Krockenberger M, et al. Anticancer Res, 2010 May. PMID 20592357.TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alpha stabilization. Sun W, et al. Clin Cancer Res, 2010 Feb 1. PMID 20103683.Glycolytic phenotype in breast cancer: activation of Akt, up-regulation of GLUT1, TKTL1 and down-regulation of M2PK. Schmidt M, et al. J Cancer Res Clin Oncol, 2010 Feb. PMID 19655166.Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia. Sanna S, et al. Hum Mol Genet, 2009 Jul 15. PMID 19419973.Overexpression of transketolase-like gene 1 is associated with cell proliferation in uterine cervix cancer. Chen H, et al. J Exp Clin Cancer Res, 2009 Mar 30. PMID 19331662.
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