癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TMEPAI Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant TMEPAI.
- 产品详情
- 实验流程
Application 
| WB, E |
|---|---|
| Primary Accession | Q969W9 |
| Other Accession | BC015918 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 2A12 |
| Calculated MW | 31609 Da |
| Gene ID | 56937 |
|---|---|
| Other Names | Protein TMEPAI, Prostate transmembrane protein androgen induced 1, Solid tumor-associated 1 protein, Transmembrane prostate androgen-induced protein, PMEPA1, STAG1, TMEPAI |
| Target/Specificity | TMEPAI (AAH15918, 181 a.a. ~ 280 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | TMEPAI Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
1.Mutation or Loss of p53 Differentially Modifies TGFβ Action in Ovarian CancerO Hainmhire E, Quartuccio SM, Cheng W, Ahmed RA, King SM, Burdette JEPLoS One. 2014 Feb 20;9(2):e89553. doi: 10.1371/journal.pone.0089553. eCollection 2014.2.TMEPAI regulates EMT in lung cancer cells by modulating the ROS and IRS-1 signaling pathways.Hu Y, He K, Wang D, Yuan X, Liu Y, Ji H, Song JCarcinogenesis. 2013 Apr 24.3.Identification of two distinct carcinoma-associated fibroblast subtypes with differential tumor-promoting abilities in oral squamous cell carcinoma.Costea DE, Hills A, Osman AH, Thurlow J, Kalna G, Huang X, Pena Murillo C, Parajuli H, Suliman S, Keerthi KK, Johannessen AC, Partridge MCancer Res. 2013 Apr 18.4.Transforming Growth Factor-{beta} (TGF-{beta})-Inducible Gene TMEPAI Converts TGF-{beta} from a Tumor Suppressor to a Tumor Promoter in Breast Cancer.Singha PK, Yeh IT, Venkatachalam MA, Saikumar P.Cancer Res. 2010 Jul 7. [Epub ahead of print]5.TMEPAI, a Transmembrane TGF-beta-Inducible Protein, Sequesters Smad Proteins from Active Participation in TGF-beta Signaling.Watanabe Y, Itoh S, Goto T, Ohnishi E, Inamitsu M, Itoh F, Satoh K, Wiercinska E, Yang W, Shi L, Tanaka A, Nakano N, Mommaas AM, Shibuya H, Ten Dijke P, Kato M.Mol Cell. 2010 Jan 15;37(1):123-34.6.A feedback loop between the androgen receptor and a NEDD4 binding protein, PMEPA1 in prostate cancer cells.Li H, Xu LL, Masuda K, Raymundo E, McLeod DG, Dobi A, Srivastava S.J Biol Chem. 2008 Oct 24;283(43):28988-95. Epub 2008 Aug 14.7.High level expression of STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 subclone.Hirokawa YS, Takagi A, Uchida K, Kozuka Y, Yoneda M, Watanabe M, Shiraishi T.Cell Mol Biol Lett. 2007 Feb 17; [Epub ahead of print]
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