癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TNP1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant TNP1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | P09430 |
| Other Accession | BC029516 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2b kappa |
| Clone Names | 1B5 |
| Calculated MW | 6424 Da |
| Gene ID | 7141 |
|---|---|
| Other Names | Spermatid nuclear transition protein 1, STP-1, TP-1, TNP1 |
| Target/Specificity | TNP1 (AAH29516.1, 1 a.a. ~ 55 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | TNP1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).
REFERENCES
The TNP1 haplotype - GCG is associated with azoospermia. Khattri A, et al. Int J Androl, 2010 May 26. PMID 20522125.Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. Aston KI, et al. Hum Reprod, 2010 Jun. PMID 20378615.Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. Pillas D, et al. PLoS Genet, 2010 Feb 26. PMID 20195514.A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Thomas G, et al. Nat Genet, 2009 May. PMID 19330030.Spermiogenesis defects in human: detection of transition proteins in semen from some infertile men. Becker S, et al. Andrologia, 2008 Aug. PMID 18727729.
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