癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TRIM16 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant TRIM16.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IP, E |
|---|---|
| Primary Accession | O95361 |
| Other Accession | NM_006470 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 5F4 |
| Calculated MW | 63955 Da |
| Gene ID | 10626 |
|---|---|
| Other Names | Tripartite motif-containing protein 16, Estrogen-responsive B box protein, TRIM16, EBBP |
| Target/Specificity | TRIM16 (NP_006461, 165 a.a. ~ 273 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IP~~N/A E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | TRIM16 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene was identified as an estrogen and anti-estrogen regulated gene in epithelial cells stably expressing estrogen receptor. The protein encoded by this gene contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. The proteins of this family have been reported to be involved in a variety of biological processes including cell growth, differentiation and pathogenesis. Expression of this gene was detected in most tissues. Its function, however, has not yet been determined.
REFERENCES
The estrogen-responsive B box protein (EBBP) restores retinoid sensitivity in retinoid-resistant cancer cells via effects on histone acetylation. Raif A, et al. Cancer Lett, 2009 May 8. PMID 19147277.The estrogen-responsive B box protein is a novel regulator of the retinoid signal. Cheung BB, et al. J Biol Chem, 2006 Jun 30. PMID 16636064.The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion. Munding C, et al. Cell Death Differ, 2006 Nov. PMID 16575408.A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070.Differential gene expression in normal human mammary epithelial cells treated with malathion monitored by DNA microarrays. Gwinn MR, et al. Environ Health Perspect, 2005 Aug. PMID 16079077.
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