癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TRIM5 Antibody (monoclonal) (M06)
Mouse monoclonal antibody raised against a partial recombinant TRIM5.
- 产品详情
- 实验流程
- 背景知识
Application 
| E |
|---|---|
| Primary Accession | Q9C035 |
| Other Accession | NM_033034 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 2A6 |
| Calculated MW | 56338 Da |
| Gene ID | 85363 |
|---|---|
| Other Names | Tripartite motif-containing protein 5, 632-, RING finger protein 88, TRIM5, RNF88 |
| Target/Specificity | TRIM5 (NP_149023, 309 a.a. ~ 418 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | TRIM5 Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
REFERENCES
Murine double minute 2 as a modulator of retroviral restrictions mediated by TRIM5alpha. Malbec M, et al. Virology, 2010 Sep 30. PMID 20619429.A TRIM5alpha exon 2 polymorphism is associated with protection from HIV-1 infection in the Pumwani sex worker cohort. Price H, et al. AIDS, 2010 Jul 31. PMID 20588169.p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha. O'Connor C, et al. J Virol, 2010 Jun. PMID 20357094.Hsp70 interacts with the retroviral restriction factor TRIM5alpha and assists the folding of TRIM5alpha. Hwang CY, et al. J Biol Chem, 2010 Mar 5. PMID 20053985.Anti-retroviral activity of TRIM5 alpha. Nakayama EE, et al. Rev Med Virol, 2010 Mar. PMID 20049904.
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