癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TRPA1 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant TRPA1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | O75762 |
| Other Accession | NM_007332 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 6G8 |
| Calculated MW | 127501 Da |
| Gene ID | 8989 |
|---|---|
| Other Names | Transient receptor potential cation channel subfamily A member 1, Ankyrin-like with transmembrane domains protein 1, Transformation-sensitive protein p120, TRPA1, ANKTM1 |
| Target/Specificity | TRPA1 (NP_015628, 1033 a.a. ~ 1117 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | TRPA1 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control.
REFERENCES
A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome. Kremeyer B, et al. Neuron, 2010 Jun 10. PMID 20547126.Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilation. Banke TG, et al. Am J Physiol Cell Physiol, 2010 Jun. PMID 20457836.TRPA1 ion channels: a gateway to airway irritation and reflex responses induced by inhaled oxidants. Lee LY. J Physiol, 2010 Mar 1. PMID 20194132.[Activation and regulation of nociceptive transient receptor potential (TRP) channels, TRPV1 and TRPA1] Tominaga M. Yakugaku Zasshi, 2010 Mar. PMID 20190512.TRPA1 expression in human lingual nerve neuromas in patients with and without symptoms of dysaesthesia. Morgan CR, et al. Neurosci Lett, 2009 Nov 13. PMID 19715741.
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