癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TSPAN1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant TSPAN1.
- 产品详情
- 实验流程
- 背景知识
Application 
| E |
|---|---|
| Primary Accession | O60635 |
| Other Accession | NM_005727 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG |
| Clone Names | 5G11 |
| Calculated MW | 26301 Da |
| Gene ID | 10103 |
|---|---|
| Other Names | Tetraspanin-1, Tspan-1, Tetraspan NET-1, Tetraspanin TM4-C, TSPAN1 |
| Target/Specificity | TSPAN1 (NP_005718, 110 a.a. ~ 211 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | TSPAN1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.
REFERENCES
Glycosylation of tetraspanin Tspan-1 at four distinct sites promotes its transition through the endoplasmic reticulum. Scholz CJ, et al. Protein Pept Lett, 2009. PMID 19508227.Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study. Lin X, et al. Diabetologia, 2009 Apr. PMID 19139842.Tspan-1 is a tetraspanin preferentially expressed by mucinous and endometrioid subtypes of human ovarian carcinomas. Scholz CJ, et al. Cancer Lett, 2009 Mar 18. PMID 19017553.Midkine promotes tetraspanin-integrin interaction and induces FAK-Stat1alpha pathway contributing to migration/invasiveness of human head and neck squamous cell carcinoma cells. Huang Y, et al. Biochem Biophys Res Commun, 2008 Dec 12. PMID 18851943.Clinicopathological significance of overexpression of TSPAN1, Ki67 and CD34 in gastric carcinoma. Chen L, et al. Tumori, 2008 Jul-Aug. PMID 18822690.
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