癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
UBE2C Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant UBE2C.
- 产品详情
- 实验流程
Application 
| WB, IHC, IF, E |
|---|---|
| Primary Accession | O00762 |
| Other Accession | NM_007019 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 9D3 |
| Calculated MW | 19652 Da |
| Gene ID | 11065 |
|---|---|
| Other Names | Ubiquitin-conjugating enzyme E2 C, UbcH10, Ubiquitin carrier protein C, Ubiquitin-protein ligase C, UBE2C, UBCH10 |
| Target/Specificity | UBE2C (NP_008950, 70 a.a. ~ 179 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | UBE2C Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
1.Ubiquitin-Conjugating Enzyme UBE2C Is Highly Expressed in Breast Microcalcification Lesions.Chou CP, Huang NC, Jhuang SJ, Pan HB, Peng NJ, Cheng JT, Chen CF, Chen JJ, Chang THPLoS One. 2014 Apr 3;9(4):e93934. doi: 10.1371/journal.pone.0093934. eCollection 2014.2.Oligonucleotide Microarray Identifies Genes Differentially Expressed during Tumorigenesis of DMBA-Induced Pancreatic Cancer in Rats.Guo JC, Li J, Yang YC, Zhou L, Zhang TP, Zhao YPPLoS One. 2013 Dec 23;8(12):e82910. doi: 10.1371/journal.pone.0082910.3.UBE2C is a marker of unfavorable prognosis in bladder cancer after radical cystectomy.Morikawa T, Kawai T, Abe H, Kume H, Homma Y, Fukayama MInt J Clin Exp Pathol. 2013 Jun 15;6(7):1367-74. Print 2013.4.Multicenter Validation of Cyclin D1, MCM7, TRIM29, and UBE2C as Prognostic Protein Markers in Non-Muscle Invasive Bladder Cancer.Fristrup N, Birkenkamp-Demtroder K, Reinert T, Sanchez-Carbayo M, Segersten U, Malmstrom PU, Palou J, Alvarez-Mugica M, Pan CC, Ulhoi BP, Borre M, Orntoft TF, Dyrskjot L.Am J Pathol. 2012 Nov 28. pii: S0002-9440(12)00811-5. doi: 10.1016/j.ajpath.2012.10.017.5.A study of UbcH10 expression and its association with recurrence of meningiomas.Jiang L, Wang T, Bao Y, Qian J, Wu XJ, Hu GH, Lu YC.J Surg Oncol. 2012 Sep 1;106(3):327-31. doi: 10.1002/jso.22141. Epub 2011 Nov 17.6.Association of clinicopathological features with UbcH10 expression in colorectal cancer.Chen S, Chen Y, Hu C, Jing H, Cao Y, Liu X.J Cancer Res Clin Oncol. 2009 Sep 25. [Epub ahead of print]7.Expression of ubiquitin-conjugating enzyme E2C/UbcH10 in astrocytic tumors.Jiang L, Huang CG, Lu YC, Luo C, Hu GH, Liu HM, Chen JX, Han HX.Brain Res. 2008 Mar 27;1201:161-6. Epub 2008 Jan 26.
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