癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
UNC119 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant UNC119.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IP |
|---|---|
| Primary Accession | Q13432 |
| Other Accession | BC027176 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 2F9-2A9 |
| Calculated MW | 26962 Da |
| Gene ID | 9094 |
|---|---|
| Other Names | Protein unc-119 homolog A, Retinal protein 4, hRG4, UNC119, RG4 |
| Target/Specificity | UNC119 (AAH27176.1, 1 a.a. ~ 240 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IP~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | UNC119 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene is specifically expressed in the photoreceptors in the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene.
REFERENCES
Uncoordinated 119 preferentially induces Th2 differentiation and promotes the development of asthma. Gorska MM, et al. J Immunol, 2010 Apr 15. PMID 20220094.UNC119 inhibits dynamin and dynamin-dependent endocytic processes. Karim Z, et al. Cell Signal, 2010 Jan. PMID 19781630.Uncoordinated 119 protein controls trafficking of Lck via the Rab11 endosome and is critical for immunological synapse formation. Gorska MM, et al. J Immunol, 2009 Aug 1. PMID 19592652.Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway. Vepachedu R, et al. J Immunol, 2007 Jul 1. PMID 17579091.Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674.
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