癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
WDR5 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant WDR5.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E |
|---|---|
| Primary Accession | P61964 |
| Other Accession | NM_017588 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 2C2 |
| Calculated MW | 36588 Da |
| Gene ID | 11091 |
|---|---|
| Other Names | WD repeat-containing protein 5, BMP2-induced 3-kb gene protein, WDR5, BIG3 |
| Target/Specificity | WDR5 (NP_060058, 16 a.a. ~ 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | WDR5 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.
REFERENCES
A Three-Stage Genome-Wide Association Study of General Cognitive Ability: Hunting the Small Effects. Davis OS, et al. Behav Genet, 2010 Mar 21. PMID 20306291.PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation. Feng W, et al. Nat Struct Mol Biol, 2010 Apr. PMID 20208542.c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. Jin S, et al. J Clin Invest, 2010 Feb 1. PMID 20093773.Regulation of HOXA2 gene expression by the ATP-dependent chromatin remodeling enzyme CHD8. Yates JA, et al. FEBS Lett, 2010 Feb 19. PMID 20085832.WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation. Wang YY, et al. Proc Natl Acad Sci U S A, 2010 Jan 12. PMID 20080758.
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