癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ZBTB33 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant ZBTB33.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q86T24 |
| Other Accession | BC042753 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 2B2 |
| Calculated MW | 74484 Da |
| Gene ID | 10009 |
|---|---|
| Other Names | Transcriptional regulator Kaiso, Zinc finger and BTB domain-containing protein 33, ZBTB33, KAISO, ZNF348 |
| Target/Specificity | ZBTB33 (AAH42753, 564 a.a. ~ 673 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | ZBTB33 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.
REFERENCES
[Bifunctional role of domain zinc fingers of methyl-DNA-binding protein Kaiso] Zhigalova NA, et al. Mol Biol (Mosk), 2010 Mar-Apr. PMID 20586187.Kaiso is expressed in lung cancer: its expression and localization is affected by p120ctn. Dai SD, et al. Lung Cancer, 2010 Feb. PMID 19615783.Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.Cytoplasmic Kaiso is associated with poor prognosis in non-small cell lung cancer. Dai SD, et al. BMC Cancer, 2009 Jun 9. PMID 19508730.Association of the mammalian transcriptional regulator kaiso with centrosomes and the midbody. Kantidze OL, et al. Cell Cycle, 2009 Jul 15. PMID 19502788.
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