癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ZW10 Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a partial recombinant ZW10.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | O43264 |
| Other Accession | NM_004724 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 2E6 |
| Calculated MW | 88829 Da |
| Gene ID | 9183 |
|---|---|
| Other Names | Centromere/kinetochore protein zw10 homolog, ZW10 |
| Target/Specificity | ZW10 (NP_004715, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | ZW10 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to kinetochore microtubules during metaphase.
REFERENCES
Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly. Chan YW, et al. J Cell Biol, 2009 Jun 1. PMID 19468067.Identification of the neuroblastoma-amplified gene product as a component of the syntaxin 18 complex implicated in Golgi-to-endoplasmic reticulum retrograde transport. Aoki T, et al. Mol Biol Cell, 2009 Jun. PMID 19369418.N-terminal region of ZW10 serves not only as a determinant for localization but also as a link with dynein function. Inoue M, et al. Genes Cells, 2008 Aug. PMID 18782227.Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint. Famulski JK, et al. J Cell Biol, 2008 Feb 11. PMID 18268100.Aurora B kinase-dependent recruitment of hZW10 and hROD to tensionless kinetochores. Famulski JK, et al. Curr Biol, 2007 Dec 18. PMID 18065224.
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