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CREB1 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
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  • 1 - CREB1 Antibody AW5058
    Western blot analysis of lysates from A549,mouse Neuro-2a,NIH/3T3,rat C6 cell line (from left to right), using CREB1 Antibody(Cat. #AW5058). AW5058 was diluted at 1:1000 at each lane. A goat anti-mouse IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.Lysates at 20ug per lane.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P16220
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Calculated MW 35136 Da
Isotype IgG1,κ
Antigen Source HUMAN
Additional Information
Gene ID 1385
Other Names Cyclic AMP-responsive element-binding protein 1, CREB-1, cAMP-responsive element-binding protein 1, CREB1
Dilution WB~~1:1000
Target/Specificity This CREB1 antibody is generated from a mouse immunized with a recombinant protein from human CREB1.
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCREB1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CREB1
Function Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (PubMed:14536081). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE-ProRule:PRU00312, ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:12552083}
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

REFERENCES

Berkowitz L.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:5258-5262(1990).
Yoshimura T.,et al.EMBO J. 9:2537-2542(1990).
Waeber G.,et al.Trans. Assoc. Am. Physicians 103:28-37(1990).
Hoeffler J.P.,et al.Science 242:1430-1433(1988).
Short M.L.,et al.Nucleic Acids Res. 19:4290-4290(1991).

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