癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TUFM Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| IF, WB |
|---|---|
| Primary Accession | P49411 |
| Other Accession | P85834, Q8BFR5, P49410 |
| Reactivity | Human, Mouse, Rat |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | polyclonal |
| Calculated MW | 49875 Da |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 7284 |
|---|---|
| Antigen Region | 112-147 aa |
| Other Names | Elongation factor Tu, mitochondrial, EF-Tu, P43, TUFM |
| Dilution | IF~~1:50~200 WB~~1:2000 |
| Target/Specificity | This TUFM antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 112-147 amino acids from the N-terminal region of human TUFM. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TUFM Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TUFM |
|---|---|
| Function | GTP hydrolase that promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Participates in mitochondrial translation (By similarity). Also plays a role in the regulation of autophagy and innate immunity (PubMed:22749352, PubMed:28407488). Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway (PubMed:28407488). In turn, inhibits RLR-mediated type I interferon while promoting autophagy (PubMed:22749352). |
| Cellular Location | Mitochondrion matrix |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
REFERENCES
Woriax V.L.,et al.Biochim. Biophys. Acta 1264:347-356(1995).
Wells J.,et al.FEBS Lett. 358:119-125(1995).
Ling M.,et al.Gene 197:325-336(1997).
Martin J.,et al.Nature 432:988-994(2004).
Dunn M.J.,et al.Submitted (MAR-1996) to UniProtKB.
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