癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MDH1 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| FC, IHC-P, WB |
|---|---|
| Primary Accession | P40925 |
| Other Accession | O88989, P11708, P14152, Q5ZME2, Q3T145 |
| Reactivity | Mouse, Rat, Human |
| Predicted | Mouse, Rat, Bovine, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 36426 Da |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 4190 |
|---|---|
| Antigen Region | 286-314 aa |
| Other Names | MDH1; MDHA; Malate dehydrogenase, cytoplasmic; Cytosolic malate dehydrogenase; Diiodophenylpyruvate reductase |
| Dilution | FC~~1:10~50 IHC-P~~1:100~500 WB~~1:1000 |
| Target/Specificity | This MDH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 286-314 amino acids from the C-terminal region of human MDH1. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MDH1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MDH1 {ECO:0000303|PubMed:34012073, ECO:0000312|HGNC:HGNC:6970} |
|---|---|
| Function | Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Catalyzes the reduction of 2-oxoglutarate to 2- hydroxyglutarate, leading to elevated reactive oxygen species (ROS) (PubMed:34012073). |
| Cellular Location | Cytoplasm, cytosol. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
MDH1 is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria.
REFERENCES
Lee,S.M., et.al., Cell Death Differ. 16 (5), 738-748 (2009)
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