|Calculated MW||H=60, 45;M=59, 45;Rat=59 KDa|
|Other Names||Transcription factor GATA-6, GATA-binding factor 6, GATA6|
|Target/Specificity||This GATA6 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 551-585 amino acids from the C-terminal region of human GATA6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GATA6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional activator (PubMed:19666519, PubMed:27756709, PubMed:22750565, PubMed:22824924). Regulates SEMA3C and PLXNA2 (PubMed:19666519). Involved in gene regulation specifically in the gastric epithelium (PubMed:9315713). May regulate genes that protect epithelial cells from bacterial infection (PubMed:16968778). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity).|
|Tissue Location||Expressed in heart, gut and gut-derived tissues|
Provided below are standard protocols that you may find useful for product applications.
Transcriptional activator that regulates SEMA3C and PLXNA2. Thought to be important for regulating terminal differentiation and/or proliferation.
Suzuki E.,et al.Genomics 38:283-290(1996).
Huggon I.C.,et al.Biochim. Biophys. Acta 1353:98-102(1997).
Yoshida T.,et al.FEBS Lett. 414:333-337(1997).
Nusbaum C.,et al.Nature 437:551-555(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.