癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
LRP12 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| FC, IF, IHC-P, WB |
|---|---|
| Primary Accession | Q9Y561 |
| Other Accession | Q8BUJ9, Q9BE74, NP_038465.1 |
| Reactivity | Mouse, Human |
| Predicted | Mouse, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 94984 Da |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 29967 |
|---|---|
| Antigen Region | 635-662 aa |
| Other Names | LRP12; ST7; Low-density lipoprotein receptor-related protein 12; Suppressor of tumorigenicity 7 protein |
| Dilution | FC~~1:10~50 IF~~1:10~50 IHC-P~~1:100~500 WB~~1:1000 |
| Target/Specificity | This LRP12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 635-662 amino acids from the C-terminal region of human LRP12. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LRP12 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LRP12 |
|---|---|
| Synonyms | ST7 |
| Function | Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor. |
| Cellular Location | Membrane; Single- pass type I membrane protein. Membrane, coated pit |
| Tissue Location | Widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas, but not in tissues consisting of a large number of epithelial cells, such as liver and kidney. Expressed at very low levels in a number of tumor-derived cell lines |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the low-density lipoprotein receptor related protein family. The product of this gene is a transmembrane protein that is differentially expressed in many cancer cells. Alternate splicing results in multiple transcript variants.
REFERENCES
Garnis, C., et al. Oncogene 23(14):2582-2586(2004)
Battle, M.A., et al. Biochemistry 42(24):7270-7282(2003)
Qing, J., et al. Oncogene 18(2):335-342(1999)
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