癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ITPA Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB |
|---|---|
| Primary Accession | Q9BY32 |
| Other Accession | Q2NLA8, D3ZW55, Q9D892, F1NLH9, Q2KIC5 |
| Reactivity | Human, Mouse, Rat |
| Predicted | Bovine, Chicken, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 21446 Da |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 3704 |
|---|---|
| Antigen Region | 24-51 aa |
| Other Names | ITPA; C20orf37; Inosine triphosphate pyrophosphatase; Non-canonical purine NTP pyrophosphatase; Non-standard purine NTP pyrophosphatase; Nucleoside-triphosphate diphosphatase; Nucleoside-triphosphate pyrophosphatase; Putative oncogene protein hlc14-06-p |
| Dilution | WB~~1:1000 |
| Target/Specificity | This ITPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-51 amino acids from the N-terminal region of human ITPA. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ITPA Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ITPA {ECO:0000255|HAMAP-Rule:MF_03148} |
|---|---|
| Synonyms | C20orf37 |
| Function | Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. |
| Cellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03148, ECO:0000269|PubMed:11278832} |
| Tissue Location | Ubiquitous. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
ITPA hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. The encoded protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency. Two transcript variants encoding two different isoforms have been found for this gene.
REFERENCES
Fellay, J., et al. Nature 464(7287):405-408(2010)
Herting, G., et al. Biochim. Biophys. Acta 1802(2):269-274(2010)
Kudo, M., et al. Drug Metab. Pharmacokinet. 24(6):557-564(2009)
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