癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GLS2 Antibody (C-term E513)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, WB |
|---|---|
| Primary Accession | Q9UI32 |
| Other Accession | P28492, Q571F8, NP_037399.2 |
| Reactivity | Mouse, Rat, Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 66323 Da |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 27165 |
|---|---|
| Antigen Region | 498-524 aa |
| Other Names | GLS2; GA; Glutaminase liver isoform, mitochondrial; L-glutaminase; L-glutamine amidohydrolase |
| Dilution | IHC-P~~1:100~500 WB~~1:1000 |
| Target/Specificity | This GLS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 498-524 amino acids from the C-terminal region of human GLS2. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GLS2 Antibody (C-term E513) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GLS2 |
|---|---|
| Synonyms | GA |
| Function | Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. |
| Cellular Location | Mitochondrion. |
| Tissue Location | Highly expressed in liver. Expressed in brain and pancreas. Not observed in heart, placenta, lung, skeletal muscle and kidney. Expression is significantly reduced in hepatocellular carcinomas. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. This protein is functionally similar to the kidney glutaminase but is a little smaller in size. Originally thought to be liver-specific, this protein has been found in other tissues as well. At least one transcribed pseudogene has been found for this gene. [provided by RefSeq].
REFERENCES
Hu, W., et al. Proc. Natl. Acad. Sci. U.S.A. 107(16):7455-7460(2010)
Suzuki, S., et al. Proc. Natl. Acad. Sci. U.S.A. 107(16):7461-7466(2010)
Szeliga, M., et al. Glia 57(9):1014-1023(2009)
Tian, C., et al. J. Neurochem. 105(3):994-1005(2008)
Maeshima, H., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry 31(7):1410-1418(2007)
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