癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SCP2 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB |
|---|---|
| Primary Accession | P22307 |
| Other Accession | O62742, P32020, P07857 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 58994 Da |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 6342 |
|---|---|
| Antigen Region | 481-515 aa |
| Other Names | Non-specific lipid-transfer protein, NSL-TP, Propanoyl-CoA C-acyltransferase, SCP-chi, SCPX, Sterol carrier protein 2, SCP-2, Sterol carrier protein X, SCP-X, SCP2 |
| Dilution | WB~~1:1000 |
| Target/Specificity | This SCP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 481-515 amino acids from the C-terminal region of human SCP2. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SCP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SCP2 (HGNC:10606) |
|---|---|
| Function | [Isoform SCPx]: Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids (PubMed:10706581). Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA) (PubMed:10706581). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro (By similarity). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl- branched fatty acyl-CoAs (By similarity). |
| Cellular Location | [Isoform SCP2]: Peroxisome {ECO:0000250|UniProtKB:P32020}. Cytoplasm. Mitochondrion. Endoplasmic reticulum {ECO:0000250|UniProtKB:P32020}. Mitochondrion {ECO:0000250|UniProtKB:P32020} |
| Tissue Location | Liver, fibroblasts, and placenta. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis.
REFERENCES
Ohba T.,et al.Genomics 24:370-374(1994).
He Z.,et al.DNA Cell Biol. 10:559-569(1991).
Yamamoto R.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:463-467(1991).
Yamamoto R.,et al.Hokkaido Igaku Zasshi 67:839-848(1992).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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