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HAO1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB |
|---|---|
| Primary Accession | Q9UJM8 |
| Other Accession | Q9WU19 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 40924 Da |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 54363 |
|---|---|
| Antigen Region | 157-185 aa |
| Other Names | Hydroxyacid oxidase 1, HAOX1, Glycolate oxidase, GOX, HAO1, GOX1, HAOX1 |
| Dilution | WB~~1:1000 |
| Target/Specificity | This HAO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 157-185 amino acids from the Central region of human HAO1. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HAO1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | HAO1 {ECO:0000303|PubMed:10978532, ECO:0000312|HGNC:HGNC:4809} |
|---|---|
| Function | Broad substrate specificity (S)-2-hydroxy-acid oxidase that preferentially oxidizes glycolate (PubMed:10777549, PubMed:10978532, PubMed:17669354, PubMed:18215067). The glyoxylate produced by the oxidation of glycolate can then be utilized by alanine-glyoxylate aminotransferase for the peroxisomal synthesis of glycine; this pathway appears to be an important step for the detoxification of glyoxylate which, if allowed to accumulate, may be metabolized to oxalate with formation of kidney stones (PubMed:10978532, PubMed:17669354). Can also catalyze the oxidation of glyoxylate, and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate, albeit with much lower catalytic efficiency (PubMed:10777549, PubMed:17669354, PubMed:18215067). Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2 (PubMed:10777549, PubMed:10978532, PubMed:17669354, PubMed:18215067). Is not active on L-lactate and 2-hydroxybutanoate (PubMed:10777549). |
| Cellular Location | Peroxisome matrix. |
| Tissue Location | Highly expressed in liver. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
HAO1 is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids.
REFERENCES
Jones,J.M., et.al., J. Biol. Chem. 275 (17), 12590-12597 (2000)
Kohler,S.A., et.al., J. Biol. Chem. 274 (4), 2401-2407 (1999)
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