癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NCOA7 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| FC, IHC-P, WB |
|---|---|
| Primary Accession | Q8NI08 |
| Other Accession | Q6DFV7 |
| Reactivity | Mouse, Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 106162 Da |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 135112 |
|---|---|
| Antigen Region | 76-103 aa |
| Other Names | Nuclear receptor coactivator 7, 140 kDa estrogen receptor-associated protein, Estrogen nuclear receptor coactivator 1, NCOA7, ERAP140, ESNA1 |
| Dilution | FC~~1:10~50 IHC-P~~1:100~500 WB~~1:2000 |
| Target/Specificity | This NCOA7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-103 amino acids from the N-terminal region of human NCOA7. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NCOA7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NCOA7 |
|---|---|
| Synonyms | ERAP140, ESNA1 |
| Function | Transcriptional coactivator which enhances the transcriptional activities of several nuclear receptors including ESR1, THRB, PPARG and RARA (PubMed:11971969). Inhibits the activity of the vacuolar-type ATPase (V-ATPase) by inducing disassembly of the V-ATPase complex (PubMed:38593795). Protects the Golgi apparatus lumen from excess acidification by inhibiting V-ATPase ATP hydrolytic activity through interaction with V-ATPase catalytic subunit ATP6V1A, maintaining optimal conditions for glycosylation enzymes (By similarity). Required to stabilize V-ATPase V1 subunits ATP6V1B2 and ATP6V1A at membrane sites (By similarity). Involved in protection against oxidative damage (PubMed:17391516, PubMed:25330068). Involved in urine acidification (By similarity). |
| Cellular Location | Nucleus. Cytoplasm. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q6DFV7}; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q6DFV7}; Peripheral membrane protein. Note=Predominantly nuclear following estradiol stimulation (PubMed:17391516). Localizes to the nucleus and cytoplasm in the absence of estradiol (PubMed:17391516). Recruited to the cis- Golgi network and trans-Golgi network membranes in a Rab-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q6DFV7, ECO:0000269|PubMed:17391516} |
| Tissue Location | Highly expressed in brain. Weakly expressed in mammary gland, ovary, uterus, prostate, stomach, bladder, spinal cord and pancreas. Expressed in cancer cell line |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
NCOA7 enhances the transcriptional activities of several nuclear receptors. It is involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA.
REFERENCES
?Arai, H., et al. Oncol. Rep. 19(6):1381-1388(2008)
?Liu, Y., et al. Schizophr. Res. 89 (1-3), 360-361 (2007) :
?Durand, M., et al. BMC Cell Biol. 8, 13 (2007) :
?Mungall, A.J., et al. Nature 425(6960):805-811(2003)
?Ohira, M., et al. Cancer Lett. 197 (1-2), 63-68 (2003) :
?Rushing, S.R., et al. Arch. Biochem. Biophys. 403(2):189-201(2002)
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