癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CRABP2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | P29373 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 15693 Da |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 1382 |
|---|---|
| Antigen Region | 102-136 aa |
| Other Names | Cellular retinoic acid-binding protein 2, Cellular retinoic acid-binding protein II, CRABP-II, CRABP2 |
| Dilution | WB~~1:1000 |
| Target/Specificity | This CRABP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-136 amino acids from the C-terminal region of human CRABP2. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CRABP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CRABP2 |
|---|---|
| Function | Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors. |
| Cellular Location | Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
A number of specific carrier proteins for members of the vitamin A family have been discovered. Cellular retinoic acid binding proteins (CRABP) are low molecular weight proteins whose precise function remains unknown. The inducibility of the CRABP2 gene suggests that this isoform is important in retinoic acid-mediated regulation of human skin growth and differentiation. It has been postulated that the CRABP2 gene is transcriptionally regulated by a newly synthesized regulatory protein. [provided by RefSeq].
REFERENCES
Sola, R., et al. Atherosclerosis 211(2):630-637(2010) Manolescu, D.C., et al. Pediatr. Res. 67(6):598-602(2010) Calmon, M.F., et al. Neoplasia 11(12):1329-1339(2009) Corlazzoli, F., et al. PLoS ONE 4 (1), E4305 (2009) : Gupta, A., et al. Exp. Cell Res. 314(20):3663-3668(2008)
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