癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Glycerol kinase (GPK2) Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, WB |
|---|---|
| Primary Accession | Q14410 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 60594 Da |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 2712 |
|---|---|
| Antigen Region | 487-515 aa |
| Other Names | Glycerol kinase 2, GK 2, Glycerokinase 2, ATP:glycerol 3-phosphotransferase 2, Glycerol kinase, testis specific 2, GK2, GKP2, GKTA |
| Dilution | IHC-P~~1:100~500 WB~~1:1000 |
| Target/Specificity | This Glycerol kinase (GPK2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 487-515 amino acids from the C-terminal region of human Glycerol kinase (GPK2). |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Glycerol kinase (GPK2) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GK2 |
|---|---|
| Synonyms | GKP2, GKTA |
| Function | Key enzyme in the regulation of glycerol uptake and metabolism. Essential for male fertility and sperm mitochondrial sheath formation (By similarity). Required for proper arrangement of crescent- like mitochondria to form the mitochondrial sheath during spermatogenesis (By similarity). Can induce mitochondrial clustering through interactions with PLD6 and up-regulation of phosphatidic acid synthesis in the mitochondria (PubMed:28852571). |
| Cellular Location | Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9WU65}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q9WU65}. Cytoplasm. Note=In sperm the majority of the enzyme is bound to mitochondria {ECO:0000250|UniProtKB:Q9WU65} |
| Tissue Location | Testis-specific (PubMed:33536340). Expressed in the midpiece of spermatozoa (PubMed:28852571) |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The human glycerol kinase gene family consists of at least 3 expressed loci. The GK1 locus on Xp21.3 is the site of mutations (deletions) causing glycerol kinase deficiency. It comprises 19 exons and is probably ancestral to several other genes which, because they are intronless, are suspected of having arisen by reverse transcriptase mediated events. These include 2 genes on chromosome 4. They are expressed as a single mRNA species in testis where expression is at a high level.
REFERENCES
Sargent, C.A., et al., Hum. Mol. Genet. 3(8):1317-1324 (1994).
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