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CHN1 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - CHN1 Antibody (N-term) AW5536
    All lanes : Anti-CHN1 Antibody (N-term) at 1:1000 dilution Lane 1: human brain lysate Lane 2: Jurkat whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 53 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P15882
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 53172 Da
Isotype Rabbit IgG
Antigen Source HUMAN
Additional Information
Gene ID 1123
Antigen Region 1-30 aa
Other Names N-chimaerin, A-chimaerin, Alpha-chimerin, N-chimerin, NC, Rho GTPase-activating protein 2, CHN1, ARHGAP2, CHN
Dilution WB~~1:1000
Target/Specificity This CHN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CHN1.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCHN1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CHN1
Synonyms ARHGAP2, CHN
Function GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.
Tissue Location In neurons in brain regions that are involved in learning and memory processes
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

This gene encodes GTPase-activating protein for p21-rac and a phorbol ester receptor. It plays an important role in ocular motor axon pathfinding. Heterozygous missense mutations in this gene cause Duane's retraction syndrome 2 (DURS2). Multiple transcript variants encoding different isoforms have been found for this gene.

REFERENCES

Volk, A.E., et al. Graefes Arch. Clin. Exp. Ophthalmol. 248(9):1351-1357(2010)
Dick, D.M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (6), 1179-1188 (2010) :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Miyake, N., et al. Am. J. Med. Genet. A 152A (1), 215-217 (2010) :
Murillo-Correa, C.E., et al. J AAPOS 13(3):245-248(2009)

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