CHN1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application ![]()
| WB |
---|---|
Primary Accession | P15882 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 53172 Da |
Isotype | Rabbit IgG |
Antigen Source | HUMAN |
Gene ID | 1123 |
---|---|
Antigen Region | 1-30 aa |
Other Names | N-chimaerin, A-chimaerin, Alpha-chimerin, N-chimerin, NC, Rho GTPase-activating protein 2, CHN1, ARHGAP2, CHN |
Dilution | WB~~1:1000 |
Target/Specificity | This CHN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CHN1. |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CHN1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CHN1 |
---|---|
Synonyms | ARHGAP2, CHN |
Function | GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance. |
Tissue Location | In neurons in brain regions that are involved in learning and memory processes |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes GTPase-activating protein for p21-rac and a phorbol ester receptor. It plays an important role in ocular motor axon pathfinding. Heterozygous missense mutations in this gene cause Duane's retraction syndrome 2 (DURS2). Multiple transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Volk, A.E., et al. Graefes Arch. Clin. Exp. Ophthalmol. 248(9):1351-1357(2010)
Dick, D.M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (6), 1179-1188 (2010) :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Miyake, N., et al. Am. J. Med. Genet. A 152A (1), 215-217 (2010) :
Murillo-Correa, C.E., et al. J AAPOS 13(3):245-248(2009)

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