癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SNRPA Antibody (Center)
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, WB |
|---|---|
| Primary Accession | P09012 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | H=31;M=32 KDa |
| Isotype | Rabbit Ig |
| Antigen Source | HUMAN |
| Gene ID | 6626 |
|---|---|
| Antigen Region | 83-111 |
| Other Names | U1 small nuclear ribonucleoprotein A, U1 snRNP A, U1-A, U1A, SNRPA |
| Dilution | WB~~1:1000 IHC-P~~1:100~1:500 |
| Target/Specificity | This SNRPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-111 amino acids from the Central region of human SNRPA. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SNRPA Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SNRPA |
|---|---|
| Function | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs. |
| Cellular Location | Nucleus. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation.
REFERENCES
Guan, F., et al. RNA 13(12):2129-2140(2007)
Hall-Pogar, T., et al. RNA 13(7):1103-1115(2007)
Shajani, Z., et al. J. Mol. Biol. 349(4):699-715(2005)
Andersen, J.S., et al. Nature 433(7021):77-83(2005)
Jessen, T.H., et al. EMBO J. 10(11):3447-3456(1991)
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