癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
beta Tubulin
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | P99024 |
| Other Accession | Q17299, P12456, P09203, Q24560, Q9YHC3, Q27U48, O17449, P36221, Q6EVK8, Q13885, Q4R5B3, Q7TMM9, P85108, Q6B856, Q9BVA1, Q9CWF2, Q3KRE8, P52275, P32882, P83130, P61858, P61857, P13602, Q2T9S0, P09206, Q13509, Q60HC2, Q9ERD7, Q4QRB4, Q3ZBU7, P04350, Q4R4X8, Q9D6F9, Q3MHM5, P68371, P86221, P68 |
| Reactivity | Human, Mouse, Rat |
| Predicted | Human, Mouse, Monkey, Dog, Sheep, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | M=50 KDa |
| Isotype | Rabbit Ig |
| Antigen Source | HUMAN |
| Gene ID | 22154 |
|---|---|
| Antigen Region | 46-78 |
| Other Names | Tubulin beta-5 chain, Tubb5 |
| Dilution | WB~~1:4000 |
| Target/Specificity | This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 46-78 amino acids from human. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | beta Tubulin is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Tubb5 |
|---|---|
| Function | Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. |
| Cellular Location | Cytoplasm, cytoskeleton |
| Tissue Location | Ubiquitously expressed with highest levels in spleen, thymus and immature brain. Expressed in embryonic brain, including throughout the developing cortex and in the subventricular zone. Also found in radial glial cells, intermediate progenitors, migrating neurons and postmitotic neurons (PubMed:23246003). Expressed in skin and developing hair follicle (PubMed:26637975). |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
REFERENCES
Wang D.,et al.J. Cell Biol. 103:1903-1910(1986).
Carninci P.,et al.Science 309:1559-1563(2005).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Lubec G.,et al.Submitted (JUL-2007) to UniProtKB.
Lewis S.A.,et al.J. Cell Biol. 101:852-861(1985).
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