癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DANRE arnt2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9DG12 |
| Reactivity | Zebrafish |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 80972 Da |
| Antigen Region | 475-501 aa |
| Gene ID | 64277 |
|---|---|
| Other Names | Aryl hydrocarbon receptor nuclear translocator 2, ARNT protein 2, zfARNT2, arnt2 {ECO:0000312|ZFIN:ZDB-GENE-001207-3} |
| Target/Specificity | This DANRE arnt2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 475-501 amino acids from the Central region of DANRE arnt2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DANRE arnt2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | arnt2 {ECO:0000312|ZFIN:ZDB-GENE-001207-3} |
|---|---|
| Function | Transcription factor that plays a role in the development of the hypothalamo-pituitary axis. Specifically recognizes the xenobiotic response element (XRE) (By similarity). Isoform 1 acts as a transcriptional activator (PubMed:11072074). Isoform 3 acts as a transcriptional repressor (PubMed:10960127, PubMed:11072074). |
| Cellular Location | Nucleus. |
| Tissue Location | Isoform 1 and isoform 2 are most highly expressed in the brain, eye and skeletal muscle and to a lower degree in liver, heart, kidney and swim bladder. Isoform 3 is most highly expressed in the eye, forebrain, midbrain, hindbrain, skeletal muscle, gills and brain but is barely detectable in liver, heart, kidney and swim bladder. Before the pharyngula period isoform 3 is expressed throughout the entire embryo and during this period extensively in the brain and eye. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Specifically recognizes the xenobiotic response element (XRE). Isoform 1 acts as a transcriptional activator. Isoform 3 acts as a transcriptional repressor.
REFERENCES
Tanguay R.L., et al. Biochim. Biophys. Acta 1494:117-128(2000).
Wang W.-D., et al. Mar. Biotechnol. 2:376-386(2000).
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