癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
(DANRE) ric8b Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q6DRJ9 |
| Reactivity | Human, Zebrafish |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Clone Names | RB48438 |
| Calculated MW | 59522 Da |
| Gene ID | 334503 |
|---|---|
| Other Names | Synembryn-B, Protein Ric-8B, Synembryn-like, ric8b, synbl |
| Target/Specificity | This DANRE ric8b antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 444-478 amino acids from the C-terminal region of DANRE ric8b. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | (DANRE) ric8b Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ric8b |
|---|---|
| Synonyms | synbl {ECO:0000303|PubMed:15256591} |
| Function | Chaperone that specifically binds and folds nascent G(s) G- alpha proteins (GNAS and GNAL) prior to G protein heterotrimer formation, promoting their association with the plasma membrane. Also acts as a guanine nucleotide exchange factor (GEF) for G(s) proteins by stimulating exchange of bound GDP for free GTP. Acts as an important component for odorant signal transduction by mediating GNAL (G(olf)- alpha) folding, thereby promoting-dependent cAMP accumulation in olfactory sensory neurons. |
| Cellular Location | Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q80XE1}. Note=Localizes to the cell cortex {ECO:0000250|UniProtKB:Q80XE1} |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
REFERENCES
Amsterdam A.,et al.Proc. Natl. Acad. Sci. U.S.A. 101:12792-12797(2004).
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¥ 1,250.00
Cat# Azb21572b
