癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
BD-1
- 产品详情
- 实验流程
| Primary Accession | O89117 |
|---|---|
| Species | Rat |
| Sequence | Asp33-Ser69 |
| Purity | > 95% as analyzed by SDS-PAGE > 95% as analyzed by HPLC |
| Endotoxin Level | < 1 EU/ µg of protein by LAL method |
| Biological Activity | Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using CD34+ dendritic cells is in a concentration range of 100.0-1000.0 ng/ml. |
| Expression System | E. coli |
| Theoretical Molecular Weight | 4.1 kDa |
| Formulation | Lyophilized from a 0.2 µm filtered solution in 20 mM PBS, 500 mM NaCl, pH 7.0. |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles. |
| Gene ID | 83687 |
|---|---|
| Other Names | Beta-defensin 1, BD-1, rBD-1, Defensin, beta 1, Defb1 |
| Target Background | Defensin are 3-4 kDa antimicrobial peptides of which three distinct families have been identified; α-defensin, β-defensins, and insect defensins. Rat β-Defensin 1, as a member of the β-defensin family, is a salt-sensitive antimicrobial peptide present in epithelia of the lung and urogenital tract. The predicted amino acid sequence shows the hallmark features of other known epithelial β-defensins, including the ordered array of six cysteine residues. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Defb1 |
|---|---|
| Function | Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. |
| Cellular Location | Secreted {ECO:0000250|UniProtKB:P60022}. Membrane {ECO:0000250|UniProtKB:P60022}. Note=Associates with tumor cell membrane-derived microvesicles. {ECO:0000250|UniProtKB:P60022} |
| Tissue Location | Highly expressed in kidney. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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