癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
C-C motif chemokine 25
- 产品详情
- 实验流程
| Primary Accession | O35903 |
|---|---|
| Sequence | MQGAFEDCCL GYQHRIKWNV LRHARNYHQQ EVSGSCNLRA VRFYFRQKVV CGNPEDMNVK RAMRILTARK RLVHWKSASD SQTERKKSNH MKSKVENPNS TSVRSATLGH PRMVMMPRKT NN |
| Purity | > 98% as analyzed by SDS-PAGE. |
| Endotoxin Level | < 0.2 EU/ µg, determined by LAL method. |
| Formulation | Lyophilized after extensive dialysis against PBS. |
| Reconstitution | Reconstituted in ddH2O or PBS at 100 µg/ml. |
| Gene ID | 20300 |
|---|---|
| Other Names | C-C motif chemokine 25, Chemokine TECK, Small-inducible cytokine A25, Thymus-expressed chemokine, Ccl25, Scya25, Teck |
| Target Background | Chemokine (C-C motif) ligand 25 (CCL25) is a small cytokine belonging to the CC chemokine family that is also known as TECK (Thymus-Expressed Chemokine). It plays a role in the development of T cells and has been shown to be chemotactic for activated macrophages, dendritic cells and thymocytes. Mouse CCL25 cDNA encodes a 144 amino acid residue precursor protein with a 23 amino acid residue signal peptide that is cleaved to yield a 121 residue mature protein. The gene for mouse CCL25 has been mapped to chromosome 8 rather than chromosome 11 where many mouse CC chemokines are clustered. Mouse CCL25 shares 49% amino acid sequence identity to with human CCL25. Recombinant Mouse TECK/CCL25 produced in E. coli is a single non-glycosylated polypeptide chain containing 122 amino acids. A fully biologically active molecule, rmTECK/CCL25 has a molecular mass of 14.3 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at . |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Ccl25 |
|---|---|
| Synonyms | Scya25, Teck |
| Function | Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. |
| Cellular Location | Secreted. |
| Tissue Location | Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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