癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
6Ckine/CCL21
- 产品详情
- 实验流程
| Primary Accession | P02775 |
|---|---|
| Species | Rat |
| Sequence | Ser24-Gln133 |
| Purity | > 95% as analyzed by SDS-PAGE |
| Endotoxin Level | < 0.2 EU/ µg of protein by gel clotting method |
| Biological Activity | The EC50 value of Rat 6Ckine/CCL21 on Ca2+ mobilization assay in CHO-K1/G15/h_CCR7 pool (human G15 and human CCR7 stably expressed in CHO-K1 cells) is less than 1.0 µg/ml. |
| Expression System | CHO |
| Formulation | Lyophilized from a 0.2 µm filtered solution in PBS. |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 µg/ml. |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
| Gene ID | 5473 |
|---|---|
| Other Names | Platelet basic protein, PBP, C-X-C motif chemokine 7, Leukocyte-derived growth factor, LDGF, Macrophage-derived growth factor, MDGF, Small-inducible cytokine B7, Connective tissue-activating peptide III, CTAP-III, LA-PF4, Low-affinity platelet factor IV, TC-2, Connective tissue-activating peptide III(1-81), CTAP-III(1-81), Beta-thromboglobulin, Beta-TG, Neutrophil-activating peptide 2(74), NAP-2(74), Neutrophil-activating peptide 2(73), NAP-2(73), Neutrophil-activating peptide 2, NAP-2, TC-1, Neutrophil-activating peptide 2(1-66), NAP-2(1-66), Neutrophil-activating peptide 2(1-63), NAP-2(1-63), PPBP, CTAP3, CXCL7, SCYB7, TGB1, THBGB1 |
| Target Background | Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine, exodus-2, and secondary lymphoid-tissue chemokine (SLC). CCL21 contains four conserved cysteines characteristic of β chemokines plus two additional cysteines in an unusually long carboxyl-terminal domain. It is expressed in lymphatic endothelial cells and the spleen. CCL21 chemoattracts T and B lymphocytes and inhibits hematopoiesis. It can signal through the CCR7 receptor. |
| Name | PPBP |
|---|---|
| Synonyms | CTAP3, CXCL7, SCYB7, TGB1, THBGB1 |
| Function | LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. |
| Cellular Location | Secreted. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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