CD20

Product Information
Primary Accession	P11836
Species	Human
Sequence	Ile141-Ser188
Purity	> 95% as analyzed by SDS-PAGE
Endotoxin Level	≤ 1 EU/ µg of protein by LAL method
Biological Activity	Immobilized Human CD20 at 1.0 µg/ml (100 µl/Well), dose response curve for rituximab with the EC₅₀ of 0.8 µg/ml determined by ELISA.
Expression System	E. coli
Formulation	Supplied as a 0.22 µm filtered solution in 20 mM PB, 10% glycerol, pH 7.0.
Storage & Stability	Upon receiving, this product remains stable for up to 6 months at -70°C or below, the product can be stored for 2-3 weeks at 2-8°C or 3 months at -20°C. Avoid repeated freeze-thaw cycles.

Additional Information
Gene ID	931
Other Names	B-lymphocyte antigen CD20, B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, CD20, MS4A1, CD20
Target Background	B-lymphocyte antigen CD20 or CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R , CD117 ) and progressively increasing in concentration until maturity.CD20 is the target of the monoclonal antibodies rituximab, ocrelizumab, obinutuzumab, ofatumumab, ibritumomab tiuxetan, tositumomab, and ublituximab, which are all active agents in the treatment of all B cell lymphomas, leukemias, and B cell-mediated autoimmune diseases.

Protein Information
Name	MS4A1
Synonyms	CD20
Function	B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes (PubMed:12920111, PubMed:3925015, PubMed:7684739). Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR (PubMed:12920111, PubMed:18474602, PubMed:7684739).
Cellular Location	Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor. Note=Constitutively associated with membrane rafts.
Tissue Location	Expressed on B-cells.