癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DLL4
- 产品详情
- 实验流程
| Primary Accession | Q9NR61 |
|---|---|
| Species | Human |
| Sequence | Ser27-Pro524 |
| Purity | > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC |
| Endotoxin Level | Less than 1EU per µg by the LAL method. |
| Biological Activity | Immobilized DLL4, Human (Cat.No.: Z03812) at 0.5 µg/ml can bind Anti-DLL4 Antibody. |
| Expression System | HEK293 |
| Theoretical Molecular Weight | 54.28 kDa |
| Formulation | Lyophilized from 0.22 µm filtered solution in PBS, 200 mM Arginine, pH 7.4. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 µg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Storage & Stability | Upon receiving, the lyophilized product remains stable up to 6 months at -20 °C or below as supplied from date of receipt.-80°C for 3 months after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| Gene ID | 54567 |
|---|---|
| Other Names | Delta-like protein 4, Drosophila Delta homolog 4, Delta4, DLL4 |
| Target Background | DLL4 is a type I membrane protein in the Delta/Serrate/Lag2 (DSL) family of Notch ligands. It activates NOTCH1 and NOTCH4, and plays a role in angiogenesis by negatively regulating endothelial cell proliferation and migration, as well as angiogenic sprouting. It is essential for retinal progenitor proliferation and is required for suppressing rod fates in late retinal progenitors, as well as for proper generation of other retinal cell types. Additionally, during spinal cord neurogenesis, it inhibits V2a interneuron fate. |
| Name | DLL4 |
|---|---|
| Function | Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Expressed in vascular endothelium. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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